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Beilstein J. Org. Chem. 2024, 20, 898–911, doi:10.3762/bjoc.20.80
Graphical Abstract
Figure 1: Uracil derivatives in drugs.
Figure 2: Present work as compared to previous studies [25,57-59].
Scheme 1: Synthesis of 1,3-dimethly-5-[2-(aryl)ethynyl]-6-[2-(aryl)ethynyl]uracils 4 and 1,3-dimethyl-5-aryl-...
Scheme 2: Synthesis of 5-bromo-1,3-dimethyl-6-[2-(aryl)ethynyl]uracils 3a–j. Reaction conditions: 2 (1.0 equi...
Scheme 3: Structure of the starting material 2 with its possible mesomeric structures.
Scheme 4: Synthesis of 1,3-dimethyl-5-[2-(aryl)ethynyl]-6-[2-(aryl)ethynyl]uracils 4a–h. Reaction conditions: ...
Scheme 5: Synthesis of 1,3-dimethyl-5-aryl-6-[2-(aryl)ethynyl]uracils 5a–t. Reaction conditions: 3 (1 equiv),...
Figure 3: ORTEP diagram of 5a front view (a) and side view (b). a) Interactions of the molecules within and b...
Figure 4: UV–vis absorption (left) and emission (right, λex = 400 nm) spectra of 1,3-dimethyl-5-phenyl-6-[2-(...
Beilstein J. Org. Chem. 2019, 15, 2830–2839, doi:10.3762/bjoc.15.276
Figure 1: Pharmacologically relevant furoindoles.
Scheme 1: Synthesis of benzo[4,5]furo[3,2-b]indoles 5a–j. Conditions: (i) 1.2 equiv 2-bromophenylboronic acid...
Figure 2: Ortep of 5c (propability of ellipsoids: 45%).
Figure 3: Diindolofurans 6a–e.
Figure 4: Illustration of binding poses of selected inhibitors for the ENPP1 homology model: (a): suramin, (b...
Figure 5: 3D poses of docked selected inhibitors inside homology model of ENPP3. (a): suramin, (b): 5e, (c): ...
Beilstein J. Org. Chem. 2013, 9, 1119–1126, doi:10.3762/bjoc.9.124
Scheme 1: Reagents and conditions: (i) CH3CN, K2CO3, rt, 24 h.
Scheme 2: Synthesis of compounds 3–8. Reagents and conditions: (i): CH3CN, K2CO3, rt, 24 h. In the case of 3-...
Figure 1: Synthesized compounds 3, 4, 6, 7.
Figure 2: Plausible reaction mechanism.
Scheme 3: The influence of K+ on the product free energy.